Gültekin M. (Yürütücü), Erzeneoğlu B., Temiz B.
Endometrial cancer is the fourth most common cancer in women, and its incidence is increasing. Early
detection is crucial since it is directly associated to patient’s survival. So far, no screening methods are
available and diagnosis is a multistep process that includes in 80% of cases a minimallyinvasive and in 20% of
cases additional invasive measures. This inaccurate diagnostic process is a burden on our healthcare system,
since it is performed on aprox. 7M women a year in EU, who will have an abnormal vaginal bleeding.
However, only 10% will have endometrial cancer. The primary goal of this proposal is to advance the
development of a non-invasive diagnostic tool of endometrial cancer using cervical fluid protein biomarkers
analyzed by advanced mathematical models. In a previous study we already discovered and verified
biomarkers in the cervical fluid. In this proposal, we will validate their potential in a cohort of 500
retrospective patients recruited by five hospitals across Spain and coordinated by Vall Hebron Hospital
(VHIR) and with the top-edge technology on targeted proteomics, led by Prof. Gunnar Dittmar (LIH partner,
Luxembourg). Molecular markers will be combined with clinical and pathological data using machine learning
techniques thanks to the USC partner (Spain). The most promising biomarker proteins will be transferred to
an antibody technology (ELISA and Electrochemical Immunosensors) by an expert SME company in this field:
ICOSAGEN (Estonian SME partner) to develop de novo antibodies, and SolarBiotec (Turkey SME partner) to
develop electrochemical biosensors and detector interfaces thereof. Through all the project, Dr. Murat
Gultekin (HU partner, Turkey) and VHIR will ensure the clinical validation of the developed non-invasive tool
and the valorization of the asset to meet stakeholder’s requirements. The resulting tool is a change in the
paradigm on how we manage endometrial cancer and will benefit patients, doctors and the health system